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主题:【原创】中医汗法的免疫学思考 -- 思想的行者

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家园 【整理】西方人惊呼在中草药中发现了“病毒青霉素"?

A Future Ebola Solution? Scientists Discover First ‘Virological Penicillin’ in Chinese Herb

Western medicine has evolved tremendously over the years. While not perfect, we are in a better situation than 100 years ago when it comes to fending off disease. One of those primary advancements came in the form of antibiotics, able to treat numerous bacterial infections (though certainly not risk-free). Now, researchers from China have discovered what they call the first ‘virological penicillin,’ which may prove to be the next ‘antibiotic for viruses.’ Even better news, it comes in the form of a natural, ancient Chinese herb. Perhaps this is what we should have been researching for the next Ebola outbreak.

外链出处

其实这个工作就是前些年发现微小RNA的横向转移的张辰宇团队做出的,科学网博客对此作了比较详细的介绍:

这篇论文不复杂,大致就是金银花(honeysuckle, HS)编码了一个miRNA基因MIR2911,能够比较光谱的作用于流感病毒(Influenza A viruse, IAV)。MIR2911在煎煮后的金银花汤液里高度稳定;持续的饮用或者喂食金银花汤液能够显著提高小鼠外周血和肺部的MIR2911表达水平;生物信息学预测和体外实验表明MIR2911可以作用各种流感病毒包括H1N1, H5N1和H7N9。合成的MIR2911能够显著抑制H1N1编码的PB2和NS1的表达;合成的MIR2911或从金银花汤液提取出的RNA能够显著抑制H1N1的病毒复制,并且恢复由病毒感染导致的小鼠体重减少;金银花汤液中生理浓度的MIR2911已能够直接及有效的抑制H1N1,H5N1和H7N9的病毒复制。口服MIR2911或金银花汤液能顾显著减少由H5N1引起的小鼠死亡。最后这些结果表明MIR2911是第一个从中药(TraditionalChinese Medicine)中发现的能过直接作用于流感病毒的活性分子。

外媒的报道

网上搜了一下,外媒的报道还是挺多的,例如:

中药里发现病毒的青霉素(‘Virological Penicillin’ Found In Chinese Traditional Medicine)

病毒的青霉素:植物MIR2911直接作用流感病毒('Virological penicillin': Plant directly targets influenza A viruses)

病毒的青霉素?(A ‘Virological Penicillin’?)这个是吐槽的,大致就是金银花的产地和品种有么有影响,另外金银花分金花和银花,究竟哪个有作用?学术质疑很正常。

Honeysuckle tea to fight flu? Chinese claim‘extremely novel finding’

By Ben Bouckley+, 08-Oct-2014

Chinese scientists are claiming an ‘extremely novelfinding’ after mice fought off several different types of flu when fed ahoneysuckle tisane.

http://www.beveragedaily.com/R-D/Honeysuckle-tea-to-fight-flu-Chinese-claim-extremely-novel-finding

金银花茶抗流感?中国宣称“极其新的发现”

科学网薛宇博文:金银花这是要成神药的节奏啊

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