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主题:PET-CT相关资料 -- xtqntd
Journal of Nuclear Medicine Vol. 46 No. 6 930-935
2005 by Society of Nuclear Medicine
Clinical Investigations
Integrated PET/CT for the Assessment of Coronary Artery Disease: A Feasibility Study
Mehdi Namdar, MD1, Thomas F. Hany, MD2, Pascal Koepfli, MD1, Patrick T. Siegrist, MD1, Cyrill Burger, PhD2, Christophe A. Wyss, MD1, Thomas F. Luscher, MD1, Gustav K. von Schulthess, MD, PhD2 and Philipp A. Kaufmann, MD1
1 Nuclear Cardiology Section, Division of Cardiology, University Hospital, Zurich, Switzerland
2 Division of Nuclear Medicine, University Hospital, Zurich, Switzerland
An accurate, noninvasive technique for the diagnosis of coronary artery disease (CAD) should provide complementary information on coronary anatomy and pathophysiologic lesion severity. We present, what is to our knowledge, the first clinical evaluation of integrated PET/CT for combined acquisition of coronary anatomy and perfusion. Methods: On an integrated PET/CT scanner, contrast-enhanced CT angiography (CTA) and rest/adenosine-stress myocardial perfusion scanning with 13N-ammonia were performed on 25 patients [COLOR=blue]with CAD documented by coronary angiography.[/COLOR] Contrast-enhanced CTA was performed with retrospective electrocardiography gating after injection of 150 mL of intravenous contrast medium. Decisions on whether to treat with revascularization (anatomic lesion plus ischemia) or conservatively (no lesion or no ischemia) based on PET/CT were compared with those based on PET plus coronary angiography. Results: Of the 100 coronary artery segments (left main, left anterior descending, left circumflex, and right in 25 patients), 7 (in 5 patients) were considered impossible to evaluate by CT because of rapid vessel movement but were correctly categorized by PET alone. In the remaining 93 segments, the sensitivity and specificity of PET/CT versus PET plus coronary angiography were 90% and 98%, respectively. Positive and negative predictive values were 82% and 99%, and accuracy was 97%. Conclusion: The data of this preliminary study suggest that PET/CT allows accurate noninvasive clinical decision making about CAD. Because of its high negative predictive value, PET/CT may play an important role in noninvasive selection of CAD patients for revascularization. Integration of higher-performance multislice spiral CT scanners into PET/CT hybrids will accelerate the clinical implementation of this technique.
在已经确诊CAD的病人诊断病情用,而不是什么在一般人群里筛检早期冠心病
- 相关回复 上下关系5
🙂这篇是比较系统的批驳 1 xtqntd 字8037 2010-05-20 23:20:55
🙂WHO Screening and early dete 1 xtqntd 字2173 2010-05-20 23:12:08
🙂关于PET-CT的特异性 1 xtqntd 字1790 2010-05-20 23:01:00
🙂所谓的PET-CT用于心梗
🙂日本人在一般人群中以PET-CT进行筛检的报道 2 xtqntd 字1861 2010-05-20 22:03:08