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主题:【原创】胡言乱语说两句西医 -- 删ID走人
Hypertension results from a complex interaction of genes and environmental factors. Numerous common genetic variants with small effects on blood pressure have been identified[34] as well as some rare genetic variants with large effects on blood pressure.[35] Also, genome-wide association studies (GWAS) have identified 35 genetic loci related to blood pressure; 12 of these genetic loci influencing blood pressure were newly found.[36] Sentinel SNP for each new genetic loci identified has shown an association with DNA methylation at multiple nearby Cpg sites. These sentinel SNP are located within genes related to vascular smooth muscle and renal function. DNA methylation might affect in some way linking common genetic variation to multiple phenotypes even though mechanisms underlying these associations are not understood. Single variant test performed in this study for the 35 sentinel SNP (known and new) showed that genetic variants singly or in aggregate contribute to risk of clinical phenotypes related to high blood pressure.[36]
Blood pressure rises with aging and the risk of becoming hypertensive in later life is considerable.[37] Several environmental factors influence blood pressure. High salt intake raises the blood pressure in salt sensitive individuals; lack of exercise, obesity, and depression[38] can play a role in individual cases. The possible role of other factors such as caffeine consumption,[39] and vitamin D deficiency[40] are less clear. Insulin resistance, which is common in obesity and is a component of syndrome X (or the metabolic syndrome), is also thought to contribute to hypertension.[41] One review suggests that sugar may play an important role in hypertension and salt is just an innocent bystander.[42]
Events in early life, such as low birth weight, maternal smoking, and lack of breastfeeding may be risk factors for adult essential hypertension, although the mechanisms linking these exposures to adult hypertension remain unclear.[43] An increased rate of high blood urea has been found in untreated people with hypertensive in comparison with people with normal blood pressure, although it is uncertain whether the former plays a causal role or is subsidiary to poor kidney function.[44] Average blood pressure may be higher in the winter than in the summer.[45]
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🙂你这是中医黑啊 8 白玉老虎 字229 2018-02-09 17:31:12
🙂建议百度:日本临床实践指南 良金百辟 字54 2018-02-09 19:20:24
🙂分类不错 1 白玉老虎 字291 2018-02-09 21:10:25
🙂wiki原发高血压病因primary hypertens
🙂大哥,我文化水平低,不懂英文。 1 删ID走人 字0 2018-02-09 20:36:01
🙂医学应该说是系统性科学,上网查到的三言两语不能治病 5 meokey 字1365 2018-02-09 13:22:31
🙂这话,欺负老百姓么? 1 潜望镜 字690 2018-02-10 10:05:06
🙂不是欺负老百姓,是不建议老百姓在网上乱查乱信 1 meokey 字15 2018-02-10 12:41:54