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主题:【原创】送给孝子:骨质疏松 -- 虽远必诛

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          • 家园 你既然说是最重要的,就要有证据

            文中提到的都是有临床试验支持。

            这种动辄就是最什么的,还没有证据的话,是混淆视听,误导他人。

            你说英国人,鸟国人的研究,也要拿出来看看是什么水平。

            实际上,多胎妊娠会导致骨质流失更快,这个同峰值骨密度有关。

            不是不可以提出其他的方式,但是说话还是严谨一点好,尤其是治病,不是闹游戏的。

            • 家园 呵呵,这个证据不容易拿出来的

              寿命的研究必然不如医学采样研究那么细致,科学。毕竟没有哪个老不死可以横跨几个世纪去完成如此复杂的研究。

              或者说,严谨的研究可能要一百多年后才能得出肯定的结论。

              Women who had "late fertility" - a birth at age 45 or older - were 14 percent to 17 percent less likely to die during any year after age 50 than women who did not deliver a child after age 40. That confirmed earlier studies. But those studies did not determine if the women gave birth later and lived longer because of genes or because of social and environmental factors such as good nutrition or healthy living.

              Brothers who had at least three sisters, including at least one sister who gave birth at age 45 or later, were 20 percent to 22 percent less likely to die during any year after age 50 than brothers who had no "late fertile" sisters. That indicates what earlier studies did not, namely, the same genes may influence the lifespan of both sexes and women's ability to give birth at older ages.

              Late motherhood boosts family lifespan

            • 家园 多胎妊娠会导致骨质流失更快

              有证据吗?

              • 家园 这个学的倒是快

                a prospective study of bone mineral density (BMD) in 38 women during their first full-term pregnancy until 12 months postpartum. BMD measurements at lumbar spine [L2–L4 (LS)] and forearm [distal 33% (RD) and ultradistal (RUD) region of the radius] were made within 3 months before conception, after delivery, and at 6 and 12 months postpartum. In mid-pregnancy the DXA examination was carried out only at the forearm. Patients were grouped according to duration of lactation as group I, II or III (0–1, 1–6, 6–12 months respectively). During pregnancy there was a significant difference between baseline and delivery (p< 0.001) in the LS, RUD and RD BMD values. In group I there was no statistically significant difference in LS BMD between visits following pregnancy. The RUD BMD loss was recovered by 6 months postpartum (PP6). Group II showed continuous bone loss from delivery until PP6 at LS and RUD. In group III the LS BMD loss continued throughout the lactation period. The RUD BMD dropped (4.9%) until PP6 then increased by 3.0% as measured at 12 months postpartum (PP12). There was no significant change in RD BMD in any of three groups during lactation. At LS bone loss between delivery and PP12 correlated well with the duration of lactation (r=0.727; p<0.001). We suggest that calcium needed for fetal skeletal growth during pregnancy was gained from maternal trabecular and cortical sites and that calcium needed for infant growth during lactation was drawn mainly from the maternal trabecular skeleton in our patients. The effect of pregnancy and lactation on the maternal bone mass was spontaneously compensated after weaning.

                The Effects of Pregnancy and Lactation on Bone Mineral Density C. More1, P. Bettembuk, H. P. Bhattoa and A. Balogh osteoporosis international 2004,04

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                • 家园 假定此研究的对象是机器人,那么可能的推论当然是

                  生得越多,骨质越疏松,自然寿命也越短。

                  但是人类研究自然不能从一个短期内就得出肯定的结论。

                  倒是有相反的证据,波士顿医学院的新英格兰百岁老人研究表明:多生晚生有利于长寿。

                  Many centenarian women have a history of bearing children after the age of 35 years and even 40 years. From our studies, a woman who naturally has a child after the age of 40 has a 4 times greater chance of living to 100 compared to women who do not (6). It is probably not the act of bearing a child in one’s forties that promotes long life, but rather, doing so may be an indicator that the woman’s reproductive system is aging slowly and that the rest of her body is as well. Such slow aging and the avoidance or delay of diseases that adversely impact reproduction would bode well for the woman’s subsequent ability to achieve very old age.

                  New England Centenarian Study

                • 家园 这个新闻肯定没有经过临床数据收集阶段

                  英国每日电讯报的这则报道却在中国流传很广。

                  Late motherhood could hold the secret to longevity

                  "The baby boomers of today are doing the right thing by having children much later - because the evidence is that the later you produce children, the longer your life span will be," said Dr Dawn Skelton of Manchester University, a leading authority on ageing.

                  She tells a television documentary to be shown next month: "After 30, there is a dramatic reduction of the oestrogen hormone in women. By leaving it longer before having our first child, we're giving ourselves a big burst of oestrogen, which helps in many ways - muscle, bone, nervous function."

                  过了一年,它又炒了次冷饭:

                  Dramatic rise in fortysomething mother

                  Later motherhood holds benefits as well as drawbacks. Older women find it more tiring but it also seems to bring longevity.

                  • 家园 这种商业报纸的报道,没有任何临床价值

                    要看在专业期刊上的,尤其是知名的期刊。如果cochrane review 说的,那么就可以作为定论了。

                    • 家园 你这个定义很狭窄,但人生苦短,等不到

                      这些杂志研究出规律。

                      但却有人发现女性百岁老人多有过四十生育的历史:

                      In their studies of centenarians, Perls and Fretts found that a surprising number of women who lived to be 100 or more gave birth in their forties. These 100-year-old women were four times as likely to have given birth in their forties as women born in the same year who died at age 73. A study of centenarians in Europe by the Max Planck Institute of Demography in Germany found the same relationship between longevity and fecundity.

                      Why Women Live Longer than Men

                      这个大概不是商业炒作吧?

    • 家园 花了再推,回复也花,我就是彪悍,带刺的玫瑰
    • 家园 我认为最好的保健方式就是人在太阳下运动

      光照的程度似乎对老人的身体健康也有影响。我注意到上海街头的老人尤其女性步履蹒跚的多,个人认为是骨质疏松引起的,乌鲁木齐的老人要明显强一些。这是否与两个城市的日照程度有关系。

      我有比较严重的颈椎增生,每年打一次钙针,葡萄糖酸钙5天,最后一天加打D针,感觉会好很多,不知对不对?

      • 家园 这两个病都讲过了,您可以看以前的帖子
      • 家园 您可以选择自己认为对的方式

        所谓的 patient's choice.

        但是从专业的角度讲,需要手足够的证据。

        没有任何证据证明骨性关节炎同日照,天气有关。

        目前流行病学调查结论是:原发性的就是遗传因素,继发性主要是外伤。

        至于说颈椎骨质增生-- 叫颈椎病比较准确,是颈椎的退行性变化 degenerative change。

        同OA 是一样的, 只能控制,无法根治。

        就是人老化了,零件不好使了。

        当然还是那句话,您自己的选择。专业角度没有任何证据钙制剂可以治疗颈椎病。

        • 家园 谢谢你的回答,可有个问题

          针对您这句

          颈椎骨质增生-- 叫颈椎病比较准确,是颈椎的退行性变化 degenerative change。

          同OA 是一样的, 只能控制,无法根治。

          就是人老化了,零件不好使了

          颈椎骨质增生一定与年纪大小有关系吗?貌似俺年纪不大呀,莫不是你暗示我人未老身先老?

          • 家园 老化,不是老了。

            所谓的aged and aging(著名的期刊,关于老年病的)。

            您今天就比昨天老了。

            关节退行变,主要是同两种因素有关。

            一:先天因素 genestic factors

            二:损伤,尤其是严重的关节损伤,车祸,运动损伤,长期的错误姿势等等。

            颈椎病还是要重视起来。去翻以前的帖子。

    • 家园 学习了

      虽远兄相见恨晚,我母亲就是前几年晚上摔了一跤就大腿骨折了,应该是骨质疏松的问题了。

      谢谢指教

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